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Do you want to know what is a bioreactor and how is it operated? How are cells cultivated for biopharmaceutical production, and what are the difficulties? In this course, you will learn the basic techniques for the successful cultivation of mammalian, plant, and stem cells.
After a course session ends, it will be archived.
Over the past 20 years, many aspects of cell cultivation techniques have become increasingly important. Today, animal and human cell cultures are used to produce antibodies to treat cancer and autoimmune and inflammatory diseases. In addition, these cells are of interest for vaccine production and gene therapies.
The current focus is on sustainability, therefore plant cell and tissue cultures have recently been used in commercial products, active ingredients in cosmetics, and food additives, and they are also used to make therapeutic enzymes. That, however, is not all. Human stem cell-based therapies and human on-chip models for testing cancer drugs and therapies are becoming more and more attractive.
Our course will provide you with a solid foundation in how to successfully cultivate the most commonly used cells for these applications. It will prepare you for the practice when you are handling these cells in the laboratory and at the same time will help you to better understand the language/concepts used by cell culture technologists. The focus will be on Chinese hamster ovary cells - CHO cells for short, mesenchymal stem cells, and plant suspension cultures.
The course requires a basic understanding of biological and technical processes. It is designed for interested learners who have little to no experience in the cultivation of different types of cell cultures.
This course consists of six units: a general introduction, the actual four teaching blocks, and the final test. The following contents are covered:
In the beginning, all organizational frameworks such as the evaluation are explained and participants can get in touch with each other via the forum.
In the 1st block "Technical basics", the technical fundamentals for the use of cell cultures in biotechnology are described. This section forms the foundation for the following blocks and will be taken up again in all subsequent units. Even if you are not a technophile, you should follow this section thoroughly, as many connections will only become apparent in the following units.
In the 2nd block, the cultivation of animal cell cultures is highlighted, with an emphasis on Chinese hamster ovary (CHO) cells. These are the most used cells for the production of monoclonal antibodies and therefore of crucial importance in pharmaceutical biotechnology.
The 3rd block deals with stem cells, with the main focus on human mesenchymal stem cells (hMSCs). This pioneering technology is the spotlight of research and will develop its full potential in the coming decades. Many working techniques from the 2nd Block can also be used here.
Block 4 will focus on plant cell cultures. Work in this field has been ongoing for a long time, but recent developments in cellular agriculture have brought a breath of fresh air. Although the basic reactor technology is similar to that of mammalian and stem cells, the working techniques used are very different from the previous blocks.
Prof. Dr. Ing., Lecturer and Head Cell Cultivation Techniques • ZHAW School of Life Sciences and Facility Management
Dipl.-Ing., Research Associate • ZHAW School of Life Sciences and Facility Management, Section for Biochemical Engineering
Dr. Ing. • ZHAW School of Life Sciences and Facility Management